Senior Scientist

We are seeking a highly motivated and technically skilled Senior Scientist with a history of scientific excellence in in vivo pharmacology to join our Oncology Small Molecules team in Waltham MA USA. As a Senior Scientist, you will be a technical leader delivering in vivo pharmacology data to support our oncology small molecules' portfolio, with a focus on drugs targeting solid tumor indications including Breast, Prostate, Lung and Colorectal cancers. To Apply: Please submit your resume and a cover letter. In your cover letter, provide specific examples of how your past experience meets the essential requirements listed below. Key Responsibilities: Apply in vivo techniques to advance our oncology pipeline by: Working hands-on in the lab developing and working with various in vivo models of cancer including subcutaneous and orthotopic xenograft models and Patient Derived Xenograft models. Designing and performing in vivo pharmacology studies (tolerability, PKPD, and efficacy) and delivering comprehensive high-quality in vivo pharmacology data packages to support early and late-stage drug discovery programs. Profiling tissue samples ex vivo to explore mechanisms of drug response and resistance using both traditional and novel approaches. Working collaboratively and cross functionally to develop and implement work plans and timelines. Working with IT programs, artificial intelligence, and databases to record all study data for broad access by project teams and partners. Essential Rquirements: In your cover letter, please provide specific examples demonstrating how your previous experience meets each of the essential requirements outlined below: BS in biology, pharmacology, or related field with a minimum of 6+ years, or MS with 4+ years, of hands-on in vivo experience. Advanced practical in vivo skills in the use of mouse models, as well as ex vivo analysis of mouse tissues. Ability to learn and apply new techniques and establish new disease models. Ability to work both independently as well as within project teams and across subject areas. Exceptional communication, listening and organizational skills. Ability to analyze, organize and present data to a diverse audience. Understanding statistical methods and quality control of data with the use of GraphPad Prism, Microsoft Office, and in vivo data capturing systems such as Study Log. Desired Requirements: PhD with a minimum of 4+ years of hands-on in vivo experience. Industry experience in technical in vivo delivery to advance drug discovery/development. Experience measuring biomarkers and using ex vivo techniques such as IHC, Western blot, ELISA, Fluidigm, MSD-based platforms. Why AstraZeneca? At AstraZeneca, we embrace opportunities for change to drive meaningful advancements. Our mission is clear: to deliver life-changing medicines and redefine possibilities in biopharma. By combining diverse perspectives, pioneering science, and bold ideas, we are transforming patient outcomes worldwide. The annual base pay (or hourly rate of compensation) for this position ranges from $108,473.60 - $162,710.40 USD Annual. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an at-will position and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors. Date Posted 24-Sep-2025 Closing Date 07-Oct-2025 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the worlds most serious diseases. But we are more than one of the worlds leading pharmaceutical companies. At AstraZeneca, were dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. Were curious about science and the advancement of knowledge. We find creative ways to approach new challenges. Were driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, youll do work that has the potential to change your life and improve countless others. And, together with your team, youll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.