Research Lab Technician I

Site: The Brigham and Women's Hospital, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary Overview: In the Nakashima Lab at the Harvey Cushing Neuro-Oncology Laboratories, within the Department of Neurosurgery at Brigham and Women's Hospital, our research is focused on the developmental immunotherapy with tumor-permissive oncolytic viruses and tumor immune mechanisms governing highly immune tolerance and resistance in brain tumors. We use advanced DNA manipulation and animal models in conjunction with the latest molecular and immunological tools in our investigation of brain tumor and immunity. We are looking for an energetic and highly organized research assistant interested in various biological and immunological experiments, including plasmid DNA, RNA, genome extraction, (RT-)PCR, Western blot, immunohistochemistry, flow cytometry, virus, cell culture, and other essential molecular biological experiments. Qualifications Description: With general supervision by the Principal Investigator, Research Fellow and Lab Manger, the Research Lab Technician will be expected to carry out designated experiments. As this research involves using murine models, the Research Lab Technician may need to assist in animal care and experiments, including transgenic colony maintenance, imaging, and health check (weekly body weight, post-surgery care). Other duties may include writing laboratory SOP, preparing various regulatory protocols such as IACUC and IBC, and data formatting with Excel, R, and other bioinformatic approaches. Requirements: Bachelors degree in biology, veterinary, neuroscience, immunology, or related field. Basic knowledge and experience with techniques of cell culture, tissue processing, molecular biology, chemistry, small animal handling and colony management skills a plus. Good laboratory practices, well organized in planning and performing lab work, maintaining good lab records and electronic notebooks are necessary. Strong motivation for curiosity-driven research, hypothesis-generation, and constant desire to improve on scientific technologies. Additional experience working in research labs or animal facilities that handle mice experience helpful; Experience with biological and immunological laboratory techniques including DNA cloning into vectors, virus propagation and titration, processing methods and analysis of DNA/RNA/protein from cells, tissues and mice, tissue culture, operations of fluorescent microscopy, flow cytometry, PCR machines, and/or ultra-centrifugation is a plus. Excellent oral and written communication skills. Ability to communicate effectively with a diverse team of researchers. Ability to make at least 1-year commitment to the position to contribute technically to newly funded NIH grant studies. Longer term contribution of more than 1 year is welcomed. As a part of the research team, your duties and responsibilities would include: Working with Dr. Nakashima and team to conduct research projects Contributing technically to the existing funded NIH grant studies and collect data for submission of the NIH grant proposal. Assisting with mouse studies, including colony maintenance, health monitoring, and in vivo imaging and post-surgery monitoring Maintaining biological material resources Documenting all research activities using a digital notebook (LabArchives) Making pre-experiment lab preparations (e.g., autoclave, reagent preparation, etc.) Attendance at all lab meetings Maintaining lab equipment NOTE: This position is grant funded. Due to the nature of experimental protocols, some off-hours work may occasionally be required. Additional Job Details (if applicable) Remote Type Onsite Work Location 60 Fenwood Road Scheduled Weekly Hours 40 Employee Type Regular Work Shift Day (United States of America) Pay Range $20.16 - $29.01/Hourly Grade 5 At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth. We invite you to apply, and our Talent Acquisition team will provide an overview of your potential compensation and benefits package. EEO Statement: 2200 The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veterans Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership looks like by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline. Combat disease. Hold a hand. Help people. Impact the world. Mass General Brigham is a passionate, welcoming community where minds meet caring hearts. Come be a part of the worlds most powerful force in medicine, where every role is important in changing lives. Are you ready? Our history includes New England hospitals founded over 200 years ago, some of the first and most prestigious hospitals in the world. Built on the legacy of two leading academic medical centers, were more than a systemwere leaders in the practice of medicine. Mass General Brigham is committed to serving the community. We are dedicated to enhancing patient care, teaching and research, and taking a leadership role as an integrated health care system. We recognize that increasing value and continuously improving quality are essential to maintaining excellence.