Research Scientist II, Biologics Engineering & Conjugation

Band Level 2 Job Description Summary #LI-Onsite Internal Job Title: Research Scientist II Location: San Diego, CA This position will be located at San Diego, CA site and will not have the ability to be located remotely. The Biologics Research Center (BRC) is seeking a highly motivated Research Scientist II with the skills and experience to contribute to advancing ADC drugs to patients in need. This is a great opportunity to join a group dedicated to protein, antibody oligonucleotide/ antibody drug conjugate discovery. The ideal candidate will possess a demonstrated expertise in protein sciences with an emphasis on protein purification, process optimization, and characterization. Responsibilities will include a range of activities related to protein purification and characterization of complex antibodies. The ideal candidate will be familiar in the design, optimization, and execution of multi-step purification, analytical data interpretation, troubleshooting and formulation of final product, while maintaining a highly productive and collaborative culture. Job Description Key Responsibilities: Independently design purification methods, understand biochemical concepts, interpret data and troubleshooting. Participate on project teams to discover, optimize, and manufacture antibody-based biologics, antibody-drug and/or oligonucleotide conjugates (ADCs/AOCs); offer technical advice at cross-functional team meetings; share technical expertise with other colleagues. Work effectively as a member of cross-functional teams to accomplish shared project goals. Special emphasis will be placed on automated antibody purification, which will involve working with Cytiva AKTA (Pure/Avant) and Unicorn software, and parallel purification using the Protein Maker. Mono and multi-specific antibody purification: preparation and packing of chromatography columns, and conducting endotoxin free chromatography, including operating preparative and analytical chromatography systems. Perform in-depth analytical characterization of molecules: endotoxin measurements, protein quantitation assays, analytical FPLC chromatography (anSEC) Coordinate the submission for supplementary biophysical characterization and interpret analytical results with area experts. Storing, inventorying, and ordering department supplies and chemicals and preparing chemical solutions according to department procedures, specifications, or supervisory instructions. Contemporaneous and accurate documentation of experiments in ELN and registration databases Contribute to patents, publications, and technical reports Essential Requirements: Bachelors or Masters degree in chemistry, biochemistry, or related discipline with 2 years of work experience, preferably in an industrial setting Understanding of biochemical concepts Expertise in protein purification Knowledge of protein and antibody sequences, antibody databases and data management systems, and ELN Exceptional organizational skills and attention to detail Excellent time management skills and multi-tasking capabilities Self motivated team player with excellent written and verbal communication Desirable Requirements: Experience in ADC/AOC purification Experience in cell binding and functional assays for antibody/ ADC/AOC characterization is desired Antibody/protein analysis and characterization including, but not limited to CE-SDS, A280, AnSEC, RP-HPLC, LC-MS, AnHIC, Endotoxin. Automated liquid handling using the Lynx The salary for this position is expected to range between $73,500 and $136,500 per year. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors. Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves. To learn more about the culture, rewards and benefits we offer our people click here. EEO Statement: The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential. Accessibility and reasonable accommodations The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to tas.nacomms@novartis.com call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message. https://www.novartis.com/careers/careers-research/notice-all-applicants-us-job-openings Salary Range $73,500.00 - $136,500.00 Skills Desired Algorithms, Algorithms, Analytical Skill, Analytical Thinking, Chemical Biology, Clinical Research, Clinical Trials, Collaboration, Communication Skills, Curiosity, Data, Data Analysis, Design Of Experiments, Detail-Oriented, Diversity & Inclusion, Drug Discovery, Ethics, Hypothesis Testing, Immunology, Laboratory, Lifesciences, Mammalian Cell Culture, Medical Research, Molecular Biology, Organization {+ 6 more} Improving the lives of people living with disease takes more than innovative science. It takes a focus on the needs of people and a community committed to meeting them. It takes a team of people like you. Working together. Learning together. Thriving together. Discover how you can join us in changing peoples lives. 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