Postdoctoral Research Fellow

About the Opportunity About the Opportunity: The Bouve College of Health Sciences is looking to hire a Post-doctoral Fellow (Medicinal Chemistry and Drug Discovery) in the Department of Pharmaceutical Sciences, Bouve College of Health Sciences, Northeastern University, Boston. Thakur Lab has been at the forefront in developing GPCR (cannabinoid receptors 1 and 2) allosteric modulators of GPCR receptor as well ligand-gated ion channel for the treatment of several diseases. Such a candidate will support the preclinical drug discovery and development for early-stage therapeutic for the treatment of neuropathic pain, glaucoma, substance use disorder, epilepsy and other disorders. Responsibilities: As a member of a this research team, this Research Scientist is expected to execute across all aspects of medicinal chemistry. The candidate will be responsible for designing, synthesizing, and optimizing molecules targeting GPCRs (cannabinoid receptors; allosteric and orthosteric) and ion channels (a4b2 nAChR, a7nAChR, a9* nAChR, GIRK1/2, GIRK1/4etc.). Key initial responsibilities will include biochemical and ADME/PK studies and data analysis, SAR hypothesis generation, empirical and structure-based target design, synthetic chemistry and troubleshooting. Our main focuses are to improve the potency/efficacy and physicochemical as well as pharmacokinetics properties of the hit molecules through chemical modification. Besides, the candidate will also work on the submission of manuscripts, patents, group reports, grant proposals and providing scientific seminars as well as mentoring and assisting junior researchers in the lab. The candidate will also be responsible for certain aspects of lab management. Qualifications: We are seeking a highly motivated and talented Medicinal Chemist with strong technical and problem-solving skills in organic and medicinal chemistry. Ph.D. in organic or medicinal chemistry with at least 1-3 years of relevant research experience with strong scientific knowledge. The candidate should have a broad understanding of GPCR as well as LGIC signaling, plotting and interpretation of data, ADME, LC-MS and an ability to develop and deliver clear and concise presentations for both internal and external meetings. Hands-on experience in GPCR signaling assays, electrophysiology assays and in-vitro/in vivo ADME/PK evaluation and computational drug discovery will be a plus. The candidate should have a strong publication record in synthetic organic and medicinal chemistry and outstanding written and verbal communication skills. Position Type Research Additional Information Northeastern University considers factors such as candidate work experience, education and skills when extending an offer. Northeastern has a comprehensive benefits package for benefit eligible employees. This includes medical, vision, dental, paid time off, tuition assistance, wellness & life, retirement- as well as commuting & transportation. Visit https://hr.northeastern.edu/benefits/ for more information. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, religion, color, national origin, age, sex, sexual orientation, disability status, or any other characteristic protected by applicable law. Compensation Grade/Pay Type: 108S Expected Hiring Range: $59,423.00 - $83,934.50 With the pay range(s) shown above, the starting salary will depend on several factors, which may include your education, experience, location, knowledge and expertise, and skills as well as a pay comparison to similarly-situated employees already in the role. Salary ranges are reviewed regularly and are subject to change. Founded in 1898, Northeastern is a global research university and the recognized leader in experiential lifelong learning. Our approach of integrating real-world experience with education, research, and innovation empowers our students, faculty, alumni, and partners to create worldwide impact. Our global university system provides our community and academic, government, and industry partners with unique opportunities to think locally and act globally. The systemwhich includes 14 campuses across the U.S., U.K., and Canada, 300,000-plus alumni, and 3,000 partners worldwideserves as a platform for scaling ideas, talent, and solutions. The universitys residential campuses for undergraduate and graduate degrees are located in Boston, London, and Oakland, California. Our research and graduate campuses are in the Massachusetts communities of Burlington and Nahant; Arlington, Virginia; Charlotte, North Carolina; Miami; Portland, Maine; Seattle; Silicon Valley, California; Toronto; and Vancouver. Northeasterns personalized, experiential undergraduate and graduate programs lead to degrees through the doctorate in 10 colleges and schools across our campuses. Learning emphasizes the intersection of data, technology, and human literacies, uniquely preparing graduates for careers of the future and lives of fulfillment and accomplishment. Our research enterprise, with an R1 Carnegie classification, is solutions oriented and spans the world. Our faculty scholars and students work in teams that cross not just disciplines, but also sectorsaligned around solving todays highly interconnected global challenges and focused on transformative impact for humankind.