Stem Cell Research Scientist

Job Description General Summary: The Stem Cell Research Scientist works with some independence and is adept at conceptually outlining studies to design and execute focused research projects or a series of complex experimental procedures including the development of human hematopoietic cell models and assays to evaluate targets and lead molecules for Vertex diseases. Completes work in a resourceful, self-sufcient manner and is able to design alternative approaches to achieve desired outcomes. Keeps current on the scientic literature relevant to scientic methodology or eld(s) of technical expertise. This level captures both the Research organizations entry level for staff with a research doctoral degree (PhD) and the advanced experimental expert leading one or more critical laboratory functions with high impact on drug discovery projects. Key Duties and Responsibilities: Designs and conducts elaborate, conceptually connected, multi-component in vitro and ex vivo experiments with primary hematopoietic cells and cell lines Collates and interprets data systematically, and synthesizes results into a cohesive body of conclusions or recommendations to guide Project decisions and new research activities Exercises solid judgment to prioritize studies, considering feasibility and Project impact Performs advanced experimental troubleshooting Scours relevant scientic literature and routinely incorporates new insights into research activities Identies, prioritizes and introduces relevant emerging technologies in eld of expertise to advance the existing technology platforms and create/maintain a competitive advantage Explores the feasibility of applying new scientic principles/concepts or implements and validates new experimental approaches and technologies to achieve project goals Contributes to patent and/or publication preparation Independently prepares study presentations and presents experimental conclusions at internal Group/Department or Project Team research meetings Performs other duties as assigned Knowledge and Skills: Ability to design and execute complex experiments including the development of human hematopoietic cell assays to evaluate targets and lead molecules for Vertex diseases Must have hands-on experience working with primary human hematopoietic cells and have experience developing and running multicolor flow cytometry and cell-based functional assays Experience with gene editing techniques Demonstrates astute understanding of own discipline and the relevant literature Maintains a high level of knowledge related to current developments in the scientic Project eld Displays proven productivity and experimental creativity, and effective dissemination of ideas Demonstrates effective, self-sufcient communication skills, especially in peer-directed presentations Demonstrates awareness of other Project-related disciplines and an understanding of general concepts and some experimental detail within those areas Education and Experience: Ph.D. (or equivalent degree) in molecular and cell biology, developmental biology, stem cell biology, or related disciplines and 0-3 years of relevant post-doctoral employment experience, or Masters Degree (or equivalent degree) in molecular and cell biology, developmental biology, stem cell biology, or related disciplines and 3+ years of relevant employment experience, or Bachelors Degree (or equivalent degree) in molecular and cell biology, developmental biology, stem cell biology, or related disciplines and 6+ years of relevant employment experience Pay Range: $104,200 - $156,200 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertexs Policy on Flex @ Vertex Program and may be changed at any time. #LI-Onsite Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency . Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortunes 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on Facebook, Twitter/X , LinkedIn, YouTube and Instagram. The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change peoples lives. Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.