Senior Scientist

Senior Scientist Do you have a passion for Bioanalysis (BA), ADME and DMPK science, applied to Cancer biology? Join AstraZeneca Oncology DMPK and help turn science into life-changing medicines for patients. About AstraZeneca AstraZeneca is a global biopharmaceutical company united by a bold ambition: to redefine cancer and restore patients lives. Oncology R&D is a major growth engine, with a diverse pipeline across all stages of development. We collaborate across disciplines to solve complex problems and bring the next generation of cancer therapies to patients. About The Site Our Waltham campus is a modern, collaborative environment with cutting-edge technology and more than 800 scientists and professionals. It is a short drive from Boston and designed to foster teamwork and cross functional science. As part of our commitment to patients and scientific excellence, we plan to relocate to Kendall Square/Cambridge in 2026, expanding our access to the world class biotech ecosystem. Business Area AstraZeneca Oncology is one of the fastest growing teams in the industry. We deliver value through scientific excellence, launch readiness, and lifecycle maximization, changing the practice of medicine through our marketed portfolio and innovative pipeline. The Oncology DMPK department provides integrated support across the portfoliobioanalysis (BA), ADME, and translational PK/PD modeling and simulation. We partner closely with discovery and development teams to generate high quality data that informs candidate selection and accelerates decision making. Role Summary We are seeking a Senior Scientist to join our ADME group in Waltham, reporting to the Director of DMPK. In this role, you will deliver BA and ADME support to Oncology discovery programs and contribute to the quantitative analysis of in vivo PK/PD studies across our global portfolio. You will collaborate with established ADME teams in Boston (US) and Cambridge (UK) and present findings in multidisciplinary settings. What you will do Independently develop and validate bioanalytical methods, analyze biological samples using quantitative LC-MS/MS assays, analyse and present findings back to project teams. Lead quality control and data review for BA to ensure accuracy, reproducibility, and regulatory readiness where applicable. Conduct operation, maintenance, and troubleshooting of key platforms: laboratory automation/liquid handling, mass spectrometers and LC equipment such as Hamilton liquid handling system, AB Sciex triple quadrupoles, HRMS and Shimadzu LC Develop and implement state-of-the-art technologies in the field of drug metabolism. Support the departments leadership team in both the strategic vision for the department and in the efficient and progressive running of the department. Ensure compliance with Good Laboratory Practice, Safety, Health and Environment standards and all other relevant internal AstraZeneca standards and external regulations. Essential Requirements BS/MS (or equivalent) in pharmaceutical sciences, chemistry, biochemistry, or related discipline, with 4+ years of industry experience. A solid foundation in bioanalytical chemistry, with demonstrated expertise in LCMS/MS, including method development and quantitative analysis. Hands-on experience with the operating, maintaining, and troubleshooting mass spectrometers and LC equipment; familiarity with laboratory automation/liquid handling and experience evaluating and implementing new bioanalytical technologies. Experience conducting in vitro mechanistic studies to address ADME-related challenges is a plus. Excellent problem-solving, organization, documentation, and communication skills; ability to thrive in a collaborative, multidisciplinary, fastpaced environment. Why AstraZeneca? At AstraZeneca, youre empowered to push the boundaries of science in an inclusive culture that champions diversity, collaboration, and lifelong learning. Theres no better place to make a meaningful impact on medicine, patients, and societyand to develop your career beyond what you thought possible. So, whats next? If youre excited by the opportunity to shape the future of oncology medicines, we want to hear from you. Apply todayand if you know someone who would be great fit, please share this opportunity. Where can I find out more? Our social media, Follow AstraZeneca on LinkedInhttps://www.linkedin.com/company/1603/ Follow AstraZeneca on Facebookhttps://www.facebook.com/astrazenecacareers/ Follow AstraZeneca on Instagramhttps://www.instagram.com/astrazeneca_careers/?hl=en The annual base pay (or hourly rate of compensation) for this position ranges from $ 109,912.80 to $164,869.20. Our positions offer eligibility for various incentivesan opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans Date Posted 23-Feb-2026 Closing Date 08-Mar-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the worlds most serious diseases. But we are more than one of the worlds leading pharmaceutical companies. At AstraZeneca, were dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. Were curious about science and the advancement of knowledge. We find creative ways to approach new challenges. Were driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, youll do work that has the potential to change your life and improve countless others. And, together with your team, youll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.