Postdoctoral Research Associate

Job TitlePostdoctoral Research Associate Agency Texas A&M University Health Science Center Department Ibt - Cedp - Dashwood Proposed Minimum Salary$5,084.00 monthly Job LocationHouston, Texas Job TypeStaff Job Description Our Commitment Texas A&M University is committed to enriching the learning and working environment by promoting a culture that respects all perspectives, talents & lived experiences. Embracing varying opinions and perspectives strengthens our core values which are: Respect, Excellence, Leadership, Loyalty, Integrity, and Selfless Service. Who we are As one of the fastest-growing academic health centers in the nation, Texas A&M Health encompasses five colleges and numerous centers and institutes working together to improve health through transformative education, innovative research and team-based health care delivery. What we want The Postdoctoral Research Associate will be involved in the identification of epigenetic and immunoepigenetic combination treatments that upregulate the MHC-I and MHC-II dependent genes to enhance host immune surveillance and anticancer efficacy. The position will support translational cancer prevention studies using cell-based systems, primary cultures, 3D spheroid/organoid models, molecular assays, immunological assays, and rodent tumor models What you need to know Salary: Will be commensurate based on the selected hires education and experience. Location/Schedule: Houston, TX/Full-Time Apply!Submitting a cover letter,CV/Resumeto assist us with the review process. You may upload these documents on the application under CV/Resume. Required Education and Experience MD/PhD in biochemistry, cell biology, immunology, cancer biology, pharmacology, molecular biology, or a related biomedical science field. Preferred Qualifications Experience with cancer biology, molecular biology, cell culture, and animal cancer models. MD/PhD with experience in translational cancer biology, cancer prevention, immunology, epigenetics, or related biomedical research. Animal cancer models, primary tissue culture, 3D spheroid/organoid cultures, molecular biology, protein biochemistry, and immunology assays. Epigenetics, HDAC biology, host immune surveillance, antigen-presentation pathways, immunoproteosome assays, with technical expertise of FACS, RNA-seq, Co-IP, ChIP, and T-cell co-culture systems. Experience in performing rodent tumor studies under approved IACUC protocols, including oral gavage, intra-venous, intra-peritoneal and subcutaneous injections Experience with antibody development, hybridoma screening, ELISA-based assays, and antibody characterization. Clinical or translational research background, including MD training or experience connecting preclinical findings to human disease relevance, is preferred. Knowledge, Skills, and Abilities Ability to multi-task and work cooperatively with others. Must be literate in the English language and be able to comprehend and follow effectively both written and verbal instructions. Excellent interpersonal, oral and written communication skills in English. Ability to do independent research in areas related to cancer immunology and epigenetics. Ability to maintain accurate records, analyze data, prepare figures and reports, and contribute to manuscripts and presentations. Responsibilities Transcriptional and epigenetic regulation of MHC Identification of epigenetic and immunoepigenetic combination treatments that upregulate MHC-I and MHC-II dependent genes to enhance host immune surveillance and anticancer efficacy. Studies may include HDAC-related mechanisms, immunoproteasome regulation, antigen-presentation pathways, and immune-response biomarkers. Molecular, cellular, and biochemical work Design and execute experiments involving epigenetic analyses, immunological assays, and molecular biology, protein biochemistry, and cancer prevention models. Experimental procedures may include tissue culture, primary cell culture, 3D spheroid/organoid culture, co-IP, ChIP, PCR, qPCR, flow cytometry/FACS, Western blotting, ELISA, HDAC activity assays, fluorescence microscopy, and related in vitro assays using wild-type and genetically modified/null cell lines. Rodent work and preclinical tumor models Conduct rodent studies according to approved protocols and the highest ethical standards. Participate in breeding and genotyping. Carefully monitor and record rodent well-being and morbidity. Perform endoscopies and polypectomies on live rodents. Perform necropsies and collection of organs for H&E, molecular, and immunohistochemical work. Administer drugs/compounds to study animals via intra-oral, intra-venous, intra-peritoneal or subcutaneous routes. Collaborations & presentations Participate actively in weekly lab meetings within the center, and with other internal and external collaborators. Participate in joint projects involving faculty, postdoctoral fellows, students, technicians, and core facility personnel. Assist with training graduate students and junior lab personnel. Support antibody core-related activities, including hybridoma screening, ELISA-based assays, and antibody characterization. Assist with research grant proposals, conference abstracts, manuscripts, figures, tables, and timely publishable reports. Conduct literature searches and contribute to new experimental approaches with rigor and reproducibility. Why Texas A&M University? We are a prestigious university with strong traditions, Core Values, and a community of caring and collaboration. Amenities associated with a major university, such as sporting and cultural events, state-of-the-art recreation facilities, the Bush Library and Museum, and much more await you. Experience all that a big city has to offer but with a reasonable cost-of-living and no long commutes. Medical, prescription drug, dental, vision, life and AD&D, flexible spending accounts, and long-term disability insurance with Texas A&M contributing to employee health and basic life premiums 12-15 days of annual paid holidays Up to eight hours of paid sick leaveand at leasteight hours of paid vacationeach month Automatic enrollment in theTeacher Retirement System of Texas Health and Wellness: Free exercise programs and release time Professional Development: All employees have access to freeLinkedIn Learningtraining, webinars, and limited financial support to attend conferences, workshops, and more Educational release time and tuition assistancefor completing a degree while a Texas A&M employee Living Well, a program at Texas A&M that has been built by employees, for employees Instructions to Applicants: Applications received by Texas A&M University must either have all job application data entered, or a resume attached. Failure to provide all job application data or a complete resume could result in an invalid submission and a rejected application. We encourage all applicants to upload a resume or use a LinkedIn profile to prepopulate the online application. All positions are security-sensitive. Applicants are subject to a criminal history investigation, and employment is contingent upon the institutions verification of credentials and/or other information required by the institutions procedures, including the completion of the criminal history check. Equal Opportunity/Veterans/Disability Employer. Howdy and thank you for your interest in a career with Texas A&M University. As the flagship campus of The Texas A&M University System, we are located in College Station, Texas with a student population of more than 74,000 and nearly 14,000 faculty and staff. The Spirit of Aggieland is unmistakable. We are a unique American institution, fostering a culture of friendliness, compassion and respect for one another. Our unique history and rich traditions make Texas A&M special. From our benefits package and professional development opportunities to our retirement programs, Texas A&M is a great place to work. Your path to a great career starts here! Equal Opportunity/Veterans/Disability Employer. If you need assistance in applying for this job, please contact (979) 845-5154. Useful Links: Benefit Programs Retirement Employee Discount Program Flexible Spending Accounts University Holidays Legal Statements New Employee Onboarding Prospective Employees Safety and Security Notices Training and Development USERRA Nondiscrimination Notice